Influence of Genetic Factors on Endometriosis(3)
In addition, people usually don't know who their nonlineal relatives are, even if they know that they think the kinship is too far away to explain in the medical record. This also makes it more difficult for researchers in other countries to diagnose the disease.
"We found that the incidence rate of endometriosis among sisters was 5.2 times higher than normal, and the probability of the first generation of cousins was low, but it was still higher than that of the control group," explains the professor Geirsson. There is a 50% similarity in the genome between sisters and 12.5% in the genome between cousins, so it has a genetic impact on the occurrence of the disease. "
The team stressed the importance of establishing a disease association between cousins. It is found that the deviation is very small by calculating the blood relationship among patients in the general population, not just between the immediate family and the first-degree relatives.
Thus, the incidence spectrum of endometriosis was established in the general population, not only in the immediate family. From the perspective of the genetic model, genetic factors have a certain impact on the occurrence of the disease, and both paternal and maternal lines have heritability.
The study found that women with endometriosis should consider pregnancy as early as possible in their childbearing age if they intend to have a baby, as the condition will worsen over time. In addition, if a woman has many symptoms of the disease or related symptoms, she and her doctor should consider doing a laparoscopy to determine or exclude the possibility of the disease.
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