Causes of Endometriosis: Immunology(2)

 

 

Macrophages are the dominant cells in peritoneal fluid leukocytes. They play an important role in the immune response. Many studies have shown that the number and activity of macrophages in the peritoneal fluid of patients with endometriosis are increased, and the secretion of il-l, TNF, PG, and other active mediators are significantly increased.

 

These substances can promote the division and proliferation of endometrial cells and fibroblasts and the deposition of fibrinogen, which is conducive to the growth of endometrium in ectopic implantation and the continuous expansion of lesions, which may be the occurrence of EMS The key to development.

 

Many studies have reported the relationship between endometriosis and cellular immune deficiency. It is believed that the abnormal immune mechanism of endometriosis can not prevent the implantation of the endometrium, and lead to its further localization and proliferation.

 

Now the question is, if EMS happens first, these immune changes are not the cause of disease, but only a pathological change; if immune changes are the first, what are the trigger factors?