Causes of Endometriosis(2)

 

 

Abnormal immune regulation plays an important role in the occurrence and development of endometriosis. As a foreign body, the endometrium that flows to the abdominal cavity with menstrual blood will activate the immune system in the body and mobilize a large number of immune cells and body fluids to eliminate. If the immune function in the body is defective, it will develop into endometriosis.

 

Endometriosis is related to some inflammation, such as peritonitis, which is manifested by the increase of macrophages, inflammatory cytokines, growth factors, and angiogenic substances in the peritoneal fluid, thus promoting the survival and proliferation of ectopic endometrium and leading to local fibroproliferation and adhesion.

 

 

 

This is a kind of artificial transplantation of endometrium to some parts, which is often seen in cesarean section, curettage in early and middle pregnancy, perineum side cutting in delivery, induced abortion, and other processes.

 

 

 

No matter the source of ectopic endometrium, its growth changes are related to the ovarian endocrine. Estrogen can promote growth and progesterone can inhibit it. It is found that most patients are lack of progesterone, which promotes the occurrence and development of the disease.

 

 

 

Environmental factors may also increase the incidence rate of endometriosis. It is found that dioxin can increase the risk of endometriosis in women. Angiogenic factors may also lead to the occurrence of endometriosis, the increase of vascular growth factors in the peritoneal fluid may lead to an increase of pelvic microvascular growth and lead to endometriosis. In addition, the decrease of apoptosis of ectopic endometrial cells may be related to the process of disease.